Oxidative Stress on Male Reproductive Toxicity

Globally Harmonized System defines Reproductive Toxicity as “an adverse effects (of chemicals) on sexual function and fertility in adult males and females, as well as developmental toxicity in the offspring.” Several toxicity assessment studies have been performed taking into account the action of toxicants on reproductive activity. Testis is the main organ of male reproductive system and spermatogenesis by itself is a highly complex differentiation process in which degeneration of spermatogenesis is an integral part of normal sperm synthesis. However, spermatogonial degeneration can also occur on exposure to toxic chemicals. This article highlights the role of environment toxicants in male infertility.